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  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is our internal ID - starting with VT.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment
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Treatment Name: Phase II Study of CDX-110 in Patients With Glioblastoma Multiforme (GBM) (ACT III)
Keywords: CDX-110, vaccine
Phase: Phase 2/3
Treatment ID#s: VT1765         NCT00458601
Age Group: Adults Only
Min Karnofsky Score: 70: Cares for self, unable to perform normal activity or to do active work
Conditions: Newly Diagnosed: Y
Recurrent: N
Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
Last Updated: 03/09/2010
Tumor Types: Glioblastoma Multiforme
Comments: This trial is for newly diagnosed patients, after having completed surgery, then the standard combination of radiation with temozolomide.

You must join within 2-3 weeks after completing radiation, but you are encouraged to talk to the participating center closest to you as soon as possible after diagnosis, as it will take some time to evaluate your eligibility. A live tumor sample is NOT required - just the sample that is usually saved after every surgery (block or slides).

CDX-110 is an immunotherapeutic molecule that is intended to induce a tumor-specific immune response in EGFRvIII positive brain cancer. Cells producing EGFRvIII have an enhanced capacity for unregulated growth, survival, invasion, and recruitment of new tumor blood vessels. This Phase II/III study is designed to determine whether the addition of CDX-110 vaccination to a standard of care regimen provides significant benefit for patients. THIS trial is not placebo controlled. Every participant gets thevaccine!

Treatment Type: Chemotherapy
Immunological, Biological or Targeted Therapy.
Contact: USC Norris Cancer Center
Thomas Chen, MD, PHD
Contact: Lydia Wilson, NP
1441 Eastlake Avenue
Los Angeles, CA 90033
Fax: (323)226-7833
Click here to send an email
UCLA Medical Center
Linda M. Liau, MD, PhD
Co-director, Brain Tumor Program
David Geffen School of Medicine at UCLA
10833 Le Conte Avenue, CHS 74-145
Los Angeles, CA 90095
Fax: 310-825-7245
Click here to send an email
UC Irvine Healthcare
Daniela Bota, MD PhD
101 The City Drive South
Orange, CA 92868
Click here to send an email
Stanford Cancer Center
Lawrence Recht, MD
Contact: Cathy Recht, RN
Palo Alto, CA 94305
Click here to send an email
U. Of California At San Francisco
Nicholas Butowski, MD
Contact Valerie Kivett
400 Parnassus Ave #0372
San Francisco, CA 94143
Fax: 415-353-2167
Click here to send an email
Yale University School Of Medicine
Joachim Baehring, M.D.
Departments of Neurology and Neurosurgery
Contact: Theresa Krause, RN
333 Cedar Street, TMP 410
New Haven, CT 06510
Click here to send an email
McKnight Brain Institute
Christine Keeling, MD
Gainsville, FL 32611
Click here to send an email
Mayo Clinic-Cancer Clinical Studies Unit
Kurt Jaeckle, MD
4500 San Pablo Road
Jacksonville, FL 32224
Email not available
Winship Cancer Institute, Emory University School of Medicine
Costas Hadjipanayis, MD
Atlanta, GA 30322
Click here to send an email
Rush University Medical Center
Robert Aiken, MD
Contact: Elizabeth Jasky, RN 312-942-2388
Chicago, IL 60612
Click here to send an email
The University of Chicago Hospitals
Maciej Lesniak, M.D.
Director, Neurosurgical Oncology
Neurosurgery, MC 3026
5841 S. Maryland Avenue
Chicago, IL 60637
Fax: 773-702-3518
Click here to send an email
Northwestern University, The Robert H. Lurie Comprehensive Cancer Center
Jeffrey Raizer, MD
Director, Medical Neuro-oncology
Contact: Lilia Gallot, MD, CCRC
Chicago, IL 60611
Click here to send an email
Kellogg Cancer Care Center
Nina Paleologos, MD
Evanston Hospital
Contact: Pat Lada
Evanston, IL
Click here to send an email
Dana-Farber Cancer Institute
Patrick Wen, MD
Center for Neuro-Oncology
Boston, MA
Email not available
The John`s Hokins Univ.
Michael Lim, MD
Contact: Bing Chao
Baltimore, MD 21287
Click here to send an email
Henry Ford Hospital
Tom MikKelsen, MD, FRCP(C)
Contact: Dr. Tom Mikelsen
Hermelin Brain Tumor Center
E&R3096 Henry Ford Hospital 2799 West Grand Blvd
Detroit, MI 48202-
Phone:313 916-8641
Fax: 313 916-9855
Click here to send an email
Edward W. Sparrow Hospital Association Sparrow Regional Cancer Center
Muhammad Hamdan, MD
Contact: Vicki Gilreath
Lansing, MI 48912
Click here to send an email
St. Mary’s of Michigan
Malcolm Field, MD
Field Neurosciences Institute
Contact: Heather Clark
Saginaw, MI 48604
Click here to send an email
The Brain Tumor Center at Duke
Henry Friedman, MD
Contact: Dr. Henry S. Friedman
Rm 047 Baker House, Hospital South
Trent Drive
Durham, NC 27710-
Fax: (919)684-6674
Click here to send an email
Hackensack University Medical Center
Viswanathan Rajaraman, MD, FRCS
Chief, Division of Neuro-oncology, Cancer Center
20 Prospect Avenue, Suite 907
Hackensack, NJ 07601
Phone:201 342 2550
Fax: 201 342 7171
Click here to send an email
Dent Neurologic Institute
Laszlo Mechtler, MD
Contact: Lori Zdrojewski
Buffalo, NY
Click here to send an email
Columbia University Medical Center
Rose Lai, MD
Contact: Mahogany Ayele, RN
New York, NY 10032
Click here to send an email
Weil Cornell Medical College-New York Presbyterian Hospital
Theodore Schwartz, MD
New York, NY 10021
Click here to send an email
SUNY Upstate Medical University at Syracuse
Gregory Canute, M.D.
Associate Professor
Department of Neurosurgery
750 East Adams Street
Syracuse, NY 13210
Fax: 315-464-6383
Click here to send an email
University Hospital – Case Medical Center
Andrew Sloan, M.D.
Contact: Christopher Murphy RN;
Cleveland, OH 44106
Click here to send an email
Cleveland Clinic Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center
Michael Vogelbaum, MD, PhD
Director, Center for Translational Therapeutics
Cleveland, OH 44195
Click here to send an email
University of Cincinnati Division of Hematology-Oncology
Margie Gerena-Lewis, MD
Contact: Alison Kasti
Columbus, OH
Click here to send an email
U. Of Pennsylvania
James Schuster, MD
3400 Spruce Street
Philadelphia, PA 19104
Click here to send an email
MD Anderson Cancer Center
Morris Groves, MD
Contact: Teresa Hanna
1400 Holcombe Blvd
Houston, TX 77030
Click here to send an email
U. of Texas at San Antonio
Aidnag Diaz, MD
San Antonio, TX 78229
Click here to send an email
University of Utah Medical Center, Huntsman Cancer Institute
Randy Jensen, MD, PhD
Dept. of Neurosurgery, 3B409 SOM
30 North 1900 East
Salt Lake City, UT 84132
Fax: 801-581-4385
Click here to send an email
University of Virginia Health System
David Schiff, MD
Co-Director, Division of Neuro-Oncology
Department of Neurology
Box 800432
Charlottesville, VA 22908-0432
Fax: 434-982-4467
Click here to send an email
Fred Hutchinson Cancer Research Center
Maciej Mrugala, MD
U. Of Washington School Of Medicine
Contact: Robyn Haaf, RN
Seattle, WA 98195
Click here to send an email

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