Trials and Noteworthy Treatments

			Treatment		Location		Last Updated
	Details		A Phase 1/11 Study of Topotecan by Intracerebral Clysis for the Treatment of Recurrent Primary Malignant Brain Tumors		NEW YORK CITY, NY		08/20/2007
	Details		Eligibility Screening Of Patients With Central Nervous System Tumors For The National Cancer Institute`s (NCI) Clinical Research Protocols		Bethesda, MD		08/20/2007
	Details		Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms		New York, NY		08/20/2007
	Details		Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor		Hamilton, Canada Perth, Western Australia, 6001, Australia Orange, CA Sacramento, CA Washington, DC St. Petersburg, FL West Palm Beach, FL Atlanta, GA Indianapolis, IN Kansas City, MO Charlotte, NC Paterson, NJ Summit, NJ New York, NY Columbus, OH Oklahoma City, OK Pittsburgh, PA San Antonio, TX Roanoke, VA Charleston, WV		08/18/2007
	Details		Phase II Trial of Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Patients with Atypical or Malignant, Primary or Metastatic Brain Tumors of the Central Nervous System		Los Angeles, CA		08/18/2007
	Details		Brain Mapping for Brain Tumors		Boston, MA		08/18/2007
	Details		Evaluation of a Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers		Cleveland, OH		05/01/2007
	Details		Comprehensive Genetic Analysis Of Brain Tumors In Children. (A Non-Therapeutic Study)		, , Canada , Canada , Canada , Canada , Canada , Canada , Switzerland , Switzerland Auckland, New Zealand Perth, Western Australia, 6001, Australia Randwick, New South Wales, 2031, Australia Phoenix, AZ Downey, CA Loma Linda, CA Los Angeles, CA Los Angeles, CA Los Angeles, CA Madera, CA Oakland, CA Orange, CA Orange, CA Sacramento, CA San Francisco, CA Santa Barbara , CA Travis Air Force Base, CA Denver, CO Farmington, CT Washington, DC Washington, DC Wilmington, DE Atlanta, GA Macon, GA Savannah, GA Des Moines, IA Chicago, IL Chicago, IL Park Ridge, IL Indianapolis, IN Springfield, MA Baltimore, MD Ann Arbor, MI Detroit, MI Grand Rapids, MI Kalamazoo, MI Royal Oak, MI Royal Oak, MI Minneapolis, MN Rochester, MN Kansas City, MO Chapel Hill, NC Charlotte, NC Winston-Salem, NC Fargo, ND Omaha, NE Omaha, NE Brunswick, NJ Newark, NJ Paterson, NJ Summit, NJ Las Vegas, NV Albany, NY Bronx, NY Brooklyn, NY Brooklyn, NY Brooklyn, NY Brooklyn, NY New Hyde Park, NY New York, NY Stony Brook, NY Syracuse, NY Akron, OH Cincinnati, OH Cleveland, OH Columbus, OH Dayton, OH Toledo, OH Portland, OR Danville, PA Philadelphia, PA Pittsburgh, PA Sioux Falls, SD Johnson City, TN Knoxville, TN Nashville, TN Amarillo, TX Austin, TX Dallas, TX Houston, TX Lubbock, TX San Antonio, TX San Antonio, TX Temple, TX Norfolk, VA Seattle, WA Seattle, WA Spokane, WA Tacoma, WA Green Bay, WI Green Bay, WI Green Bay, WI La Crosse, WI Madison, WI Marshfield, WI Marshfield, WI Huntington, WV		10/12/2006
	Details		Pilot Randomized Study of Modafinil for Treatment of Fatigue and Neurobehavioral Dysfunction in Patients With Primary Brain Tumors		Los Angeles, CA		05/29/2006
	Details		Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors		Washington, DC Chicago, IL Boston, MA Bethesda, MD Philadelphia, PA Pittsburgh, PA Memphis, TN Houston, TX Seattle, WA		05/27/2006
	Details		Phase 3 study: Radiation Therapy and Combination Chemotherapy Followed by Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor		Durham, NC Memphis, TN Houston, TX		05/02/2006
	Details		"Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival.		Oakland, CA		05/01/2006
	Details		Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors		Oakland, CA		05/01/2006
	Details		Pharmacological intervention for learning impaired children surviving treatment for cancer.		Durham, NC		12/03/2005
	Details		Gamma Knife Radiosurgery		Smithtown, NY		12/03/2005
	Details		Gamma Knife Radiosurgery for Brain Tumors		La Jolla, CA		12/03/2005
	Details		Phase I trial of Temozolomide (Temodar) and O6-Benzylguanine (o6-bg)in pediatric patients with recurrent brain tumors.		Durham, NC		12/03/2005
	Details		A Phase I dose escalation trial of Temodar that will attempt to determine the maximum tolerated dose of Temodar (Temozolomide) when given by prolonged oral exposure to children with recurrent or progressive brain tumors.		New York, NY		12/03/2005
	Details		Gamma Knife Radiosurgery		Edison, NJ		12/03/2005
	Details		Gamma knife stereotactic radiosurgery for benign and malignant brain tumors and brain metastases.		Rockville Centre, NY		12/03/2005
	Details		Quality of Life Studies (There are 19 seperate studies listed here)		Durham, NC		12/03/2005
	Details		Treatment of newly diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor (PNET), or Atypical Teratoid Rhabdoid Tumor (ATRT)		Memphis, TN		12/03/2005
	Details		A Phase I/II Study of Reirradiation for Recurrent Pediatric Brain and Spinal Cord Tumors and Primary Glioblastoma Multiforme Using the Photon Radiosurgery System		Chicago, IL		11/27/2005
	Details		A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors		Bethesda, MD Bethesda, MD		11/27/2005
	Details		Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer		New York, NY		11/27/2005
	Details		A Phase I, Molecular Biology, and Phase II Study of Lapatinib (GW572016) in Pediatric Patients with Recurrent or Refractory Medulloblastoma, Malignant Glioma or Ependymoma		Washington, DC Chicago, IL Boston, MA Bethesda, MD Durham, NC Philadelphia, PA Pittsburgh, PA Memphis, TN Memphis, TN Houston, TX Seattle, WA		11/27/2005
	Details		Computer Assisted Stereotactic Navigation For Resection Of Brain Tumors In Children And Adults		Hackensack, NJ		11/27/2005
	Details		Double sequential high dose Thiotepa with autologous stem cell rescue for patients age <60 years with recurrent malignant brain cancer.		Los Angeles, CA		11/27/2005
	Details		Endoscopic ventriculostomy for obstructive hydrocephalus in terminal patients with hydrocephalus and brain tumours.		Kelantan, Malaysia, MALAYSIA		11/27/2005
	Details		Functional brain Mapping Of Motor And Speech Areas For Resection Of Tumors Near Functional Areas Of The Brain		Hackensack, NJ		11/27/2005
	Details		Genetic Therapy of meningiomas and gliomas in the Malay population in the NorthnEast coast of Malaysia		Kelantan, Malaysia, MALAYSIA		11/27/2005
	Details		Pilot Study of Systemic and Intrathecal Chemotherapy Followed by Conformal Radiation for Infants with Brain Tumors		Durham, NC Memphis, TN Houston, TX		11/27/2005
	Details		Regulus Navigator for use with a three point pinion - frameless stereotactic surgery		New York, NY		11/27/2005
	Details		Volumetric Stereotactic Procedures		New York, NY		11/27/2005
	Details		Gamma Knife Radiosurgery for Brain Tumors and Arteriovenous and Cavernous Malformations		St.Petersburg, Fl		11/26/2005
	Details		Reduced Dose Craniospinal Radiation (1800 cGy) and Chemotherapy in children with newly-diagnosed standard-risk posterior fossa primitive neuro-ectodermal tumor (PNET/medulloblastoma )		Palo Alto, CA Egleston, GA Philadelphia, PA		11/26/2005
	Details		Use of interferon for the treatment of gliomas of the brain and spine.		Kelantan, Malaysia, MALAYSIA		11/26/2005
	Details		Aggresive emergency tumour debulking and craniectomy for patients with tumours of more than 80ml and glasgow coma scale of less than 8.		Kelantan, Malaysia, MALAYSIA		11/26/2005
	Details		Computer assisted minimally invasive image guided surgery for improved resection of malignant brain tumors and frameless stereotactic brain biopsies For Deep Brain Tumors.		Smithtown, NY		11/26/2005
	Details		Headstart II A Phase II study of two alternative intensive induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous stem cell rescue with or without subsequent radiation therapy for children less than 10 yrs of age newly diagnosed with malignant brain tumors		New York, NY		11/26/2005
	Details		Intraoperative navigation in neurosurgical patients		Boston, MA		11/26/2005
	Details		Phase I study of Photodynamic Therapy with porfimer sodium for refractory brain tumors		Milwaukee, WI		11/26/2005
	Details		Frameless Computer Assisted Stereotactic Surgery for Resection of Brain Tumors in Adults and Children		Rockford, IL		11/25/2005
	Details		Frameless Computer Guided Stereotactic Sugery for Resection of Brain Tumors in Adults and Children		Rockford, IL		11/25/2005
	Details		Brain tumor surgery using a compact intraoperative MRI		Manhasset, NY		11/25/2005
	Details		"Head Start" chemotherapy protocol for children less than 10 years old with newly diagnosed high grade primary brain tumors with intent to eliminate irradiation and abbreviate total duration of treatment to 6 months with resultant improved cure rate and quality of survival.		Los Angeles, CA		11/20/2005
	Details		Intraoperative MRI for brain tumors		Boston, MA		11/20/2005
	Details		Phase I/II trial of ZD1839 (Iressa) in pediatric patients newly diagnosed with brain stem tumors or incompletely resected supratentorial malignant gliomas.		Durham, NC		11/13/2005
	Details		Natural History of Patients with Brain and Spinal Cord Tumors		Bethesda, MD		11/13/2005
	Details		Pilot study of genetic and environmental Risk and outcome for newly diagnosed brain tumor patients and controls.		Durham, NC		11/13/2005
	Details		Pilot trial of Innohep (Tinzaparin) Low Molecular Weight Heparin for primary prophylaxis of venous thromboembolism in brain tumor patients.		Durham, NC		11/13/2005
	Details		Neurocognitive Prognosis in Survivors of Brain Tumors		Charlottesville, VA		11/13/2005
	Details		Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Central Nervous System Cancer		New York, NY		11/11/2005
	Details		VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors		Washington, DC Chicago, IL Boston, MA Bethesda, MD Durham, NC Philadelphia, PA Pittsburgh, PA Memphis, TN Houston, TX Seattle, WA		11/11/2005
	Details		Phase II study of Oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors and atypical teratoid rhabodoid tumors.		Durham, NC		11/09/2005
	Details		Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment		, Puerto Rico Fort Myers, FL Gainesville, FL Jacksonville, FL Pensacola, FL St. Petersburg, FL Tampa, FL West Palm Beach, FL Augusta, GA Indianapolis, IN Grand Rapids, MI Syracuse, NY Akron, OH San Antonio, TX San Antonio, TX Temple, TX Richmond, VA Green Bay, WI		11/06/2005
	Details		Phase I study of Cilengitide in children with refractory brain tumors.		Durham, NC		11/06/2005
	Details		Radiosurgery with the Varian Trilogy system for benign or malignant brain tumors		Mobile , AL		11/06/2005

News Stories

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•   (0.8658)   Improving Treatment of Medulloblastoma, a Common Childhood Brain Tumor;
•   (0.8510)   Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma
•   (0.8351)   Technique Could Speed New Medulloblastoma Drugs
•   (0.8351)   Post-Therapy Damage Seen on MRI Scans of Medulloblastoma Patients Can Be Mistaken for New Tumors
•   (0.8351)   Results of a Randomized Study of Preradiation Chemotherapy Versus Radiotherapy Alone for Nonmetastatic Medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children`s Cancer Study Group PNET-3 Study.
•   (0.8169)   Autumn Birth Linked to Childhood Brain Cancer
•   (0.8169)   Clinical, Histopathologic, and Molecular Markers of Prognosis: Toward a New Disease Risk Stratification System for Medulloblastoma.
•   (0.8169)   A flower that causes birth defects in grazing sheep has offered valuable clues about treating brain tumors in children, researchers said on Thursday. [Applies to Medulloblastoma]
•   (0.8169)   New Treatment Likely to Increase Survival Rates in Patients with Medulloblastoma -- a Rare Pediatric Brain Tumor (PR Newswire)
  An ongoing study at St. Jude Children`s Research Hospital indicates that a new treatment protocol could increase survival rates for some pediatric brain cancers to 80 percent for high-risk and 90 percent for standard-risk.
  - May 11 7:30 AM ET
•   (0.7967)   The Samantha Dickson Research Trust has become the largest funder of laboratory based brain tumour research in the UK, and offers a vital support link for brain tumour patients and their families or carers.
•   (0.7967)   Autumn Birth Linked to Childhood Brain Cancer
•   (0.7967)   Health Highlights: Feb. 20, 2002 (HealthSCOUT)
  ...About 75 percent of patients with the hard-to-treat form of cancer saw their tumors shrink after a single dose of the drug, the Associated Press reports.......-- Some Brain Tumors May Be Linked to Virus A common virus that usually lies dormant in as many as 70 percent...... in as many as 70 percent of all children may be responsible for a particular type of brain tumor, BBC News Online reports.......Medulloblastoma is the most common type of cancer to afflict the brains of children, the report says. Researchers from Temple University found that children suffering...
  - Feb 20 11:55 PM ET
•   (0.7742)   Prenatal Vitamins May Fend Off Some Childhood Brain Tumors
•   (0.7742)   Functional VEGF and VEGF receptors are expressed in human medulloblastomas
•   (0.7742)   Young Girl Fighting For Her Life (KGTV TheSanDiegoChannel.com)
  ...-- a cancer that causes tumors in the brain and spinal column -...
  - Jan 22 8:56 PM ET
•   (0.7742)   Insight Into Brain Tumor Spread May Aid Treatment (Reuters)
  Researchers have identified the underlying genetic regulation of an invasive type of brain tumor called medulloblastoma--a finding they say could lead to new strategies to prevent the spread of this tumor.
  - Sep 03 7:42 PM ET
•   (0.7742)   New gene target found for common brain tumors in children
•   (0.7742)   Extraneural metastases of paediatric brain tumours

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