Glioblastoma Multiforme
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 For People with Newly Diagnosed Glioblastoma Multiforme
NovoCure Trial
The NovoTTF is a portable, investigational external device for cancer treatment using Tumor Treating Fields.
The device is used in addition to the standard treatments.
 For People with Reccurent Glioblastoma Multiforme (and other malignant gliomas)
Toca 511 with 5-FC:
Clinical trials in progress for recurrent malignant glioma.
Click here to learn more.

Trials and Noteworthy Treatments

  Treatment Next 25 Location Last Updated
Details Phase II Double-Blinded Placebo-Controlled Study Of Bevacizumab with or without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma Cincinnati, OH 03/14/2013
Details A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study Evaluating the Efficacy and Safety of Onartuzumab in Combination with Bevacizumab or Onartuzumab Monotherapy in Patients with Recurrent Glioblastoma San Francisco, CA 10/08/2012
Details An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma(The “ACT IV” Study) San Francisco, CA 10/08/2012
Details Protocol H9H-MC-JBAI - Phase 1b/2a Study Combining LY2157299 with Standard Temozolomide-based Radiochemotherapy in Patients with Newly Diagnosed Malignant Glioma San Francisco, CA 10/08/2012
Details Protocol H9H-MC-JBAL- A Phase 2 Study of LY2157299 Monohydrate Monotherapy or LY2157299 Monohydrate plus Lomustine Therapy compared to Lomustine Monotherapy in Patients with Recurrent Glioblastoma San Francisco, CA 10/08/2012
Details A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma (ReACT) Cincinnati, OH 09/26/2012
Details Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV) Cincinnati, OH 09/26/2012
Details Study of a Drug [DCVax®-Brain] to Treat Newly Diagnosed GBM Brain Cancer Cincinnati, OH 09/26/2012
Details A Phase I First-in-Human Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 595 in Subjects With Recurrent Malignant Glioma Expressing Mutant Epidermal Growth Factor Receptor Variant III (EGFRvIII) Cincinnati, OH 09/26/2012
Details A Randomized Phase I/II Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma Cincinnati, OH 09/26/2012
Details A Study of ICT-107(Vaccine therapy) in Glioblastoma Multiforme (GBM) Birmingham, AL
Tucson, AZ
La Jolla, CA
Los Angeles, CA
Tampa, FL
Chicago, IL
Chicago, IL
Louisville, KY
Winston-Salem, NC
Edison, NJ
New Brunswick, NJ
Summit, NJ
Great Neck & Commack, NY
Cleveland, OH
Cleveland, OH
Hershey, PA
Philadelphia, PA
Dallas, TX
Houston, TX
Charlottesville, VA
09/24/2012
Details A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma (ReACT) Birmingham, AL
Phoenix, AZ
Los Angeles, CA
Stanford, CA
Gainesville, FL
Atlanta, GA
Chicago, IL
Evanston, IL
Boston, MA
Lansing, MI
Durham, NC
Great Neck, NY
Cincinnati, OH
Cleveland, OH
Cleveland, OH
Philadelphia, PA
Providence, RI
Dallas, TX
Houston, TX
Salt Lake City, UT
Seattle, WA
09/22/2012
Details Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV) Birmingham, AL
Mobile, AL
Little Rock, AR
Phoenix, AZ
Duarte, CA
La Jolla, CA
Los Angeles, CA
Orange, CA
Palo Alto, CA
Sacramento, CA
San Francisco, CA
Vista, CA
Hartford, CT
New Haven, CT
Miami Beach, FL
Orlando, FL
Atlanta, GA
Iowa City, IA
Chicago, IL
Chicago, IL
Evanston, IL
Lexington, KY
Annapolis, MD
Baltimore, MD
Bethesda, MD
Ann Arbor, MI
Lansing, MI
Saginaw, MI
Minneapolis, MN
St. Louis, MO
Durham, NC
Lincoln, NE
Lebanon, NH
Edison, NJ
Hackensack, NJ
Brooklyn, NY
Buffalo, NY
Great Neck, NY
Manhasset, NY
New York, NY
Rochester, NY
Syracuse, NY
White Plains, NY
Cincinnati, OH
Cleveland, OH
Cleveland, OH
Portland, OR
Portland, OR
Allentown, PA
Philadelphia, PA
Pittsburgh, PA
Charleston, SC
Nashville, TN
Nashville, TN
Dallas, TX
Houston, TX
Houston, TX
Salt Lake City, UT
Burlington, VT
Seattle, WA
Seattle, WA
Madison, WI
Milwaukee, WI
09/22/2012
Details Study of a Drug [DCVax®-Brain] to Treat Newly Diagnosed GBM Brain Cancer Duarte, CA
La Jolla, CA
Los Angeles, CA
Newport Beach, CA
Orange, CA
Sacramento, CA
Washington, DC
Miami Beach, FL
Chicago, IL
Chicago, IL
Peoria, IL
Lexington, KY
Boston, MA
Ann Arbor, MI
Detroit, MI
Minneapolis, MN
Kansas City, MO
St. Louis, MO
Chapel Hill, NC
Hackensack, NJ
Summit, NJ
Great Neck & Commack, NY
Manhasset, NY
Rochester, NY
White Plains, NY
Cincinnati , OH
Cincinnati, OH
Cincinnati, OH
Cleveland, OH
Cleveland, OH
Columbus, OH
Philadelphia, PA
Providence, RI
Charleston, SC
Nashville, TN
Nashville, TN
Dallas, TX
Seattle, WA
09/22/2012
Details Safety and Efficacy Study of Lucanthone When Used in Combination With Temozolomide(TMZ) and Radiation to Treat Glioblastoma Multiforme(GBM) Buffalo, NY
Cleveland, OH
07/19/2012
Details A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Tocagen Toca 511 in Patients with Recurrent Glioblastoma Multiforme La Jolla, CA
Los Angeles, CA
San Francisco, CA
Detroit, MI
Cleveland, OH
07/16/2012
Details Study of a Retroviral Replicating Vector (Tocagen Toca 511) to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor Los Angeles, CA
Detroit, MI
Edison, NJ
Cleveland, OH
Columbus, OH
Seattle, WA
07/16/2012
Details Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma [New concept in treating brain tumors: Interlaced Therapy!] Atlanta, GA
Baltimore, MD
Detroit, MI
Winston-Salem, NC
07/04/2012
Details Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Graz, Austria
Prague, Czech Republic
Lyon, France
Paris, France
Toulouse, France
Hamburg, Germany
Heidelberg, Germany
Kiel, Germany
Tel Aviv, Israel
Milan, Italy
Milan, Italy
Rome, Italy
Lanne, Switzerland
La Jolla, CA
Los Angeles, CA
Orlando, FL
Tampa, FL
Chicago, IL
Boston, MA
Boston, MA
Burlington, MA
Scarborough, ME
Edison, NJ
New York, NY
New York, NY
Cleveland, OH
Danville, PA
Pittsburgh, PA
Dallas, TX
Houston, TX
Houston, TX
Houston, TX
Seattle, WA
04/29/2012
Details Plexxicon, Inc - A Phase 2 Study of Orally Administered PLX3397 in Patients With Recurrent Glioblastoma San Francisco, CA 04/24/2012
Details A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Tumors of the Brain San Francisco, CA 04/05/2012
Details A Phase II study of BKM120 for patients with recurrent glioblastoma and activated PI3K pathway at first relapse San Francisco, CA 04/05/2012
Details N0874/ABTC09-02: Phase I/II Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]), Temozolomide, and Radiation Therapy in Patients with Newly Diagnosed Glioblastoma San Francisco, CA 04/05/2012
Details Phase I/II Trial of Oral Erlotinib (Tarceva, OSI-774) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma New York, NY 03/10/2012
Details A Phase 1 and 2 Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Springfield, IL 02/26/2012


News Stories

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Frequently Asked Questions



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  (0.7967)   Is the combination of Dendritic Cell Vaccine and oncolytic viruses possible and/or evaluated for the treatment of recurrent Glioblastoma Multiforme? If yes, what are the results, the pro~s and con~s, and where is this therapy evaluated?

  (0.7967)   What is your opinion on Dr Burzynskis antineoplaston therapy for brain tumors?

  (0.7967)   How do you get a brain tumor? What can you do to treat a brain tumor? Can you prevent a brain tumor? Will it ever just go away by itself? Why do you go into a coma? How long are you in a coma before you die? What percent of Americans have brain tumors? Is it likely since my great grandmother had a brain tumor that I will?

  (0.7967)   My husband was diagnosed with Glioblastoma Multiforme about 4 months ago. He has had surgery, radiation and chemotherapy; right now we are waiting to have an MRI done. He had his last treatment in August. What is next? What can I expect from here? Are there any new treatments or research available?

  (0.7967)   My sister-in-law just had surgery to remove a tumor identified as glioblastoma multiforme. The tumor was the size of a lemon. The doctor says that if it recurs, she is not a candidate for another surgery. How likely is ? What are the chances of complete recovery?

  (0.7967)   Having reviewed some statistical information, I still want to know: how many GBMs are diagnosed say, in a year, or by state, or by country. If, on average, a neurosurgeon only treats one per year, they canno be THAT common, can they?

  (0.7742)   My mother has been diagnosed with Glioblastoma Multiforme, tumor location: brain stem. She had a stereotactic biopsy and the doctor prescribed 40 radiation treatments with daily intake of Temodal 140mg. The radiation treatment clinic doesn~t work on weekends, so she goes 5 weekdays and pauses for 2 day week-end. However, the doctor told her to take Temodal even for week-ends till the rest of radiation treatment. That means that she would end up taking Temodal for 56 days! On the information sheet for Temodal, it is stated that Temodal should be taken for 42, up to 49 days max! Could you please tell me is it safe for my mother to take Temodal longer then 49 days? Is it safe to follow our doctor~s orders in continuing with Temodal until the end of 40 week-day radiation treatment (and end up taking Temodal for 56 days)? Should she continue taking Temodal on week-ends when she doesn~t go for radiation treatment?

  (0.7742)   My friend was diagonized in early May, 2004, with Glioblastoma Multiforme. He had surgery, radiation, and chemotherapy. After radiation, they did an MRI and it showed a new growth so he started the chemotherapy and, after four chemo treatments, they did another MRI and it had gotten bigger. They now want to do another surgery and try a different chemo. Are there any significant things we should worry about with the second surgery and, since it is still growing after radiation and chemotherapy, what are his chances of survival and how long?

  (0.7742)   What is the difference between diffuse astrocytoma grade three, a GBM, and AA grade three? Is it common for low white counts and low platelet counts to continually delay temodar treatments by a couple of weeks?

  (0.7742)   My 57-year-old brother has Glioblastoma Multiforme. He is on steroids and has been since Oct. Within the last five weeks, he has been bruising easily/bleeding on his lower arms and wrists. Does anyone know how this can be prevented? All he is done thus far is cover his lower arms with gauze! If someone could get back to me before 4:00 p.m. today, it would be greatly appreciated! Also, as long as we are on the subject, does anyone know of a doctor in New Jersey that is willing to work "outside the box" and supplement chemotherapy with additives, such as verapimil, tamoxifen, etc.?

  (0.7742)   My father was diagnosed with Glioblastoma Multiforme in mid-December 2003. The tumor is located in the left frontoparietal area and was thus deemed inoperable. He is about to begin the sixth and final week of radiation. He has also gone through his first round of chemotherapy (Temodar). During the course of his treatment, he has been going to work daily. Over the course of the last five weeks, his right side mobility had improved substantially and his radio-oncologist expressed cautious optimism regarding his prognosis. However, just as he is to begin his sixth week of radiation, he lost his balance twice and fell, and has lost some of the movement in his right arm. My question is: what can cause such deterioration of his neurological condition? Can it be explained by exhaustion, a side-effect of the treatment, or that the treatment has not halted the tumor's growth?

  (0.7742)   My father has just been diagnosed with Glioblastoma Multiforme. He is starting radiation tomorrow. I want to get him on some nutritional supplements to help out with energy, weight loss, hair loss, etc. I have some specific products from a company for which I am an Independent Distributor. Some of the products do have herbs in them. My first question is: my sister's concern that some herbs will make the tumor grow more. Have you ever heard of anything to this effect? Then secondly, I am under the impression that antioxidants are not absorbed when going through radiation treatment. Is this correct or does it hinder the radiation treatment in any way? I ask because the multivitamin I would like him to take does have antioxidants in it. Maybe I should be asking a nutritionist this. Any thoughts on this?





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